Antiresorptive and Anabolic Bone Therapy Does not Improve Weight Bearing Capacity and Bone Strength in OA Rats
نویسندگان
چکیده
Methods: Medial meniscectomy was used to induce OA in male Lewis rats. Therapy with zoledronate and human PTH was initiated immediately after surgery. A dynamic weight-bearing system was deployed to evaluate the weight-bearing capacity. At the end of the 10-week study cartilage pathology was evaluated by contrast μCT imaging and histology. Cortical bone geometry at femoral mid-diaphysis was evaluated by μCT and strength was tested using 3-point bending method.
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